DEPARTMENT OF BIOCHEMISTRY


Dr. PÉTER NAGY

Head of Centre
Biological Sciences

CV
Dr.KRISZTINA KŐHALMI

Head of Department
Biological Sciences

CV


Staff

Lászlóné Weiner, Dr. BorbálaVincze, PhD Head of Department, Candidate in Biological Sciences
Dr.Krisztina Kőhalmy Chemist, PhD
Dr. Viktória Mile Chemist, PhD
Bence Kapuvári Chemist, PhD candidate
Judit Kovács Chemist
Beatrix Susztrik Head assistant
Éva Képiró Laboratory assistant
Beáta Akacs Laboratory assistant
Andrásné Vukovics Laboratory assistant

Professional activity

The professional activities of the Department are divided into the following three main groups:

1. Research area:
Scientific collaboration with various clinical and research departments of the Institute and multilateral cooperation with other domestic institutions and research centres. This is to assist the development and use of cancer diagnostic and/or prognostic results, and the effectiveness of the therapy investigations. Within these the two main directions are:
a) Development of bioconjugates for targeted tumor therapy of cancer types leading to high mortality (Principal investigator: Prof. Dr. Mező Gábor, NKFI-6, K, 119552).
b)Research on biochemical markers of cancer diseases.

2. Development and application of tumor diagnostic and prognostic studies on the effectiveness of therapy:
a) Determination of serum parameters, and circulating biomarkers, in prostate cancer related to progression and efficacy of therapy (in collaboration with Department of Medical Oncology and Clinical Pharmacology “C”, Dr. Lajos Géczi (head of the department), permission from Medical Research Council Scientific and Research Committee was received, ad.18409-4/2016/EKU)
b) Importance of serum “Thymus and Activation-Regulated Chemokine" (TARC) determination in primary mediastinal large B-cell lymphoma (in collaboration with Department of Oncological Internal Medicine „A”, Dr. Tamás Schneider (head of department))
c) Simultaneous determination of L-citrulline and L-arginine in plasma by high performance liquid chromatography, method setting and performing measurements (in cooperation with Department of Medical Oncology and Clinical Pharmacology “C”)
d) Determination of sulfoconjugated steroid hormone precursor and sexual hormone levels present in the circularity system, and study their diagnostic and prognostic value in endometrium carcinoma (in cooperation with Gynecological Department, Dr. Zoltán Novák (head of department), Dr. Boglárka Balázs)

3. The Department of Biochemistry carries out regularly the next routine diagnostic laboratory tests for the purpose of patient care using biochemical and radiochemical (RIA / IRMA) and ELISA techniques:
a) Determining the diagnostic and prognostic serum markers of thyroid cancer during the postoperative follow-up (calcitonin, thyreoglobulin (Tg), anti-Tg antibodies (TgAb)).
b) A more detailed study of endocrine status in hormone dependent tumors such as breast, prostate, testicular, and gynecological cancers. Determining levels of serum sexual hormone, and their precursors during patients’ therapy.
c) Measurement of serum TARC concentrations in classical Hodgkin lymphoma (cHL) patients.
d) Investigatiom of serum inhibin B levels in ovarian cancer patients with granulosa cell tumors.
e) Determination of dihydropyrimidine dehydrogenase (DPD) enzyme activity to predict the toxic side effect of a cytotoxic drug 5-fluorouracil (5-FU). The measurement is available only in our department in Hungary.
f) In vitro diagnostics of neuroendocrine tumors. Determination of serum chromogranin A, and 24 h urine vanillylmandelic acid, homovanillic acid, metanephrine, normetanephrine and 5-hydroxyindoleacetic acid concentrations.
In 2018 the Department of Biochemistry performed 13,586 routine diagnostic tests for 6608 patient cases.

Education and training activities

The staff of the Department of Biochemistry also carry out educational activities in higher education and in other professional (PhD, qualification) training. In close cooperation with the Central Laboratory, the Department participates in residency training with theoretical and practical lectures.
- Performing practical training courses for chemical, bio and genetic engineer students
- Mentoring a BsC Bioengineer student from the Budapest University of Technology and Economics, Faculty of Chemical Technology and Biotechnology in their thesis
- Conducting postgraduate courses
- Translations of international medical papers
- Department of Biochemistry staff regularly participate in professional training courses and events
- Dr. Krisztina Kőhalmy, Dr. Vikória Mile and Judit Kovács are currently participating in Clinical Biochemistry Postgraduate courses (Semmelweis University, Department of Laboratory Medicine)

+36 (1) 224 8600
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